Trypanosome alternative oxidase: from molecule to function.

  title={Trypanosome alternative oxidase: from molecule to function.},
  author={Minu Chaudhuri and Robert Daniel Ott and G. Craig Hill},
  journal={Trends in parasitology},
  volume={22 10},
Trypanosome alternative oxidase (TAO) is the cytochrome-independent terminal oxidase of the mitochondrial electron transport chain. TAO is a diiron protein that transfers electrons from ubiquinol to oxygen, reducing the oxygen to water. The mammalian bloodstream forms of Trypanosoma brucei depend solely on TAO for respiration. The inhibition of TAO by salicylhydroxamic acid (SHAM) or ascofuranone is trypanocidal. TAO is present at a reduced level in the procyclic form of T. brucei, where it is… CONTINUE READING
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The effect of over-expression of the alternative oxidase in the procyclic forms of Trypanosoma brucei

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  • Mol. Biochem. Parasitol
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Trypanosome alternative oxidase exists as a monomer in Trypanosoma brucei mitochondria

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