Trypanosoma cruzi subverts the sphingomyelinase-mediated plasma membrane repair pathway for cell invasion

@inproceedings{Fernandes2011TrypanosomaCS,
  title={Trypanosoma cruzi subverts the sphingomyelinase-mediated plasma membrane repair pathway for cell invasion},
  author={Maria Cec{\'i}lia Di Ciero Fernandes and Mauro Cortez and Andrew R. Flannery and Christina W Tam and Renato Arruda Mortara and Norma W Andrews},
  booktitle={The Journal of experimental medicine},
  year={2011}
}
Upon host cell contact, the protozoan parasite Trypanosoma cruzi triggers cytosolic Ca(2+) transients that induce exocytosis of lysosomes, a process required for cell invasion. However, the exact mechanism by which lysosomal exocytosis mediates T. cruzi internalization remains unclear. We show that host cell entry by T. cruzi mimics a process of plasma membrane injury and repair that involves Ca(2+)-dependent exocytosis of lysosomes, delivery of acid sphingomyelinase (ASM) to the outer leaflet… CONTINUE READING

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