Trypanosoma cruzi maxicircle heterogeneity in Chagas disease patients from Brazil.

  title={Trypanosoma cruzi maxicircle heterogeneity in Chagas disease patients from Brazil.},
  author={Julio C{\'e}sar Carranza and Helder Magno Silva Valadares and Daniella A D'{\'a}vila and Rodrigo de Paula Baptista and Margoth Moreno and L{\'u}cia M C Galv{\~a}o and Egler Chiari and Nancy R. Sturm and Eliane Costa Dias Macedo Gontijo and Andr{\'e}a Mara Macedo and Bianca Zingales},
  journal={International journal for parasitology},
  volume={39 9},
The majority of individuals in the chronic phase of Chagas disease are asymptomatic (indeterminate form, IF). Each year, approximately 3% of them develop lesions in the heart or gastrointestinal tract. Cardiomyopathy (CCHD) is the most severe manifestation of Chagas disease. The factors that determine the outcome of the infection are unknown, but certainly depend on complex interactions amongst the genetic make-up of the parasite, the host immunogenetic background and environment. In a previous… CONTINUE READING
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