Trypanosoma cruzi infection in immunosuppressed mice.

  title={Trypanosoma cruzi infection in immunosuppressed mice.},
  author={K{\'a}tia da Silva Calabrese and P. G. Bauer and P. H. Lagrange and Sylvio Celso Gonçalves da Costa},
  journal={Immunology letters},
  volume={31 1},
Groups of 10 mice were challenged with 10(4) trypomastigotes of the Y strain of Trypanosoma cruzi. Cyclophosphamide (200 mg per kg) was used for immunosuppression and administered two days before infection in one group and on day 5 after infection in a second group. Enhancement of infection was more drastic in the second group, with a uniform acceleration of mortality and no clearance of the blood parasites. Electron microscopy showed that the hepatocytes were colonized by T. cruzi and that the… CONTINUE READING