Trypanosoma cruzi infection in MHC-deficient mice: further evidence for the role of both class I- and class II-restricted T cells in immune resistance and disease.

@article{Tarleton1996TrypanosomaCI,
  title={Trypanosoma cruzi infection in MHC-deficient mice: further evidence for the role of both class I- and class II-restricted T cells in immune resistance and disease.},
  author={Rick L. Tarleton and M. J. Grusby and Miriam Postan and L. H. Glimcher},
  journal={International immunology},
  year={1996},
  volume={8 1},
  pages={13-22}
}
The role of T cell population in immune control of Trypanosoma cruzi infection and subsequent development of disease has been examined using gene knockout mice deficient in the expression of either or both class I and Class II MHC. Mice deficient in either class I- or class II-restricted T cell populations show a striking similarity in their mortality rate, parasite load and tissue inflammatory response following infection with the Brazil strain of T. cruzi. In both cases all animals died… CONTINUE READING

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