Trypanosoma cruzi disrupts myofibrillar organization and intracellular calcium levels in mouse neonatal cardiomyocytes

@article{Taniwaki2005TrypanosomaCD,
  title={Trypanosoma cruzi disrupts myofibrillar organization and intracellular calcium levels in mouse neonatal cardiomyocytes},
  author={Noemi Nosomi Taniwaki and Fabiana Sim{\~a}o Machado and Andr{\'e} Ricardo Massensini and Renato Arruda Mortara},
  journal={Cell and Tissue Research},
  year={2005},
  volume={324},
  pages={489-496}
}
Immunofluorescence studies of normal and Trypanosoma cruzi-infected primary cultures of heart muscle cells were performed to gather information about the arrangement of myofibrillar components during the intracellular life cycle of this parasite. By using a panel of monoclonal antibodies against various myofibrillar proteins, a progressive disruption and loss of contractile proteins (such myosin and actin) of the host cell was detected during infection. The host cell formed a loose network of… CONTINUE READING