Trypanosoma cruzi chemical proteomics using immobilized benznidazole.

  title={Trypanosoma cruzi chemical proteomics using immobilized benznidazole.},
  author={Andrea Trochine and Guzm{\'a}n {\'A}lvarez and Sandra Corre and Paula Faral-Tello and Rosario Duran and Carlos Batthyany and Hugo Cerecetto and Mercedes Gonz{\'a}lez and Carlos Robello},
  journal={Experimental parasitology},
Benznidazole (Bzn) is a nitroimidazole drug currently used as first line treatment against Chagas disease, a neglected tropical disease caused by the flagellated protozoan Trypanosoma cruzi. Although the drug has been used since the late 1960s, its mechanism of action is not fully understood. In an attempt to study Bzn mode of action, a structurally modified derivative of the drug was synthesized and immobilized into a solid matrix. This allowed enrichment of T. cruzi proteins capable of… CONTINUE READING