Trypanosoma cruzi-cardiomyocyte interaction: role of fibronectin in the recognition process and extracellular matrix expression in vitro and in vivo.

@article{Calvet2004TrypanosomaCI,
  title={Trypanosoma cruzi-cardiomyocyte interaction: role of fibronectin in the recognition process and extracellular matrix expression in vitro and in vivo.},
  author={Cl{\'a}udia Magalh{\~a}es Calvet and Marcus Meuser and Danielle Santos de Almeida and Maria de Nazareth Leal de Meirelles and M{\'i}rian S. C. Pereira},
  journal={Experimental parasitology},
  year={2004},
  volume={107 1-2},
  pages={20-30}
}
We investigated the involvement of fibronectin (FN) in Trypanosoma cruzi-cardiomyocyte invasion and the extracellular matrix (ECM) components expression during T. cruzi infection in vivo and in vitro. Treatment of trypomastigotes with FN or a synthetic peptide (MRGDS) prior to cardiomyocyte interaction reduced T. cruzi infection, indicating that FN mediates the parasite invasion through its RGD sequence. In murine experimental Chagas' disease, an enhancement of the ECM components was detected… CONTINUE READING