Trypanosoma cruzi Utilizes the Host Low Density Lipoprotein Receptor in Invasion

  title={Trypanosoma cruzi Utilizes the Host Low Density Lipoprotein Receptor in Invasion},
  author={Fnu Nagajyothi and Louis M Weiss and David L Silver and Mahalia Sabrina Desruisseaux and Phillip E Scherer and Joachim Herz and Herbert B Tanowitz},
  booktitle={PLoS neglected tropical diseases},
BACKGROUND Trypanosoma cruzi, an intracellular protozoan parasite that infects humans and other mammalian hosts, is the etiologic agent in Chagas disease. This parasite can invade a wide variety of mammalian cells. The mechanism(s) by which T. cruzi invades its host cell is not completely understood. The activation of many signaling receptors during invasion has been reported; however, the exact mechanism by which parasites cross the host cell membrane barrier and trigger fusion of the… CONTINUE READING


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