Trypanosoma cruzi Needs a Signal Provided by Reactive Oxygen Species to Infect Macrophages

@inproceedings{Goes2016TrypanosomaCN,
  title={Trypanosoma cruzi Needs a Signal Provided by Reactive Oxygen Species to Infect Macrophages},
  author={Grazielle Ribeiro Goes and Peter S. Rocha and Aline R. S. Diniz and Pedro Henrique Nascimento Aguiar and Carlos Renato Machado and Leda Quercia Vieira},
  booktitle={PLoS neglected tropical diseases},
  year={2016}
}
BACKGROUND During Trypanosoma cruzi infection, macrophages produce reactive oxygen species (ROS) in a process called respiratory burst. Several works have aimed to elucidate the role of ROS during T. cruzi infection and the results obtained are sometimes contradictory. T. cruzi has a highly efficiently regulated antioxidant machinery to deal with the oxidative burst, but the parasite macromolecules, particularly DNA, may still suffer oxidative damage. Guanine (G) is the most vulnerable base and… CONTINUE READING
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