Trypanosoma cruzi High Mobility Group B (TcHMGB) can act as an inflammatory mediator on mammalian cells

@inproceedings{Cribb2017TrypanosomaCH,
  title={Trypanosoma cruzi High Mobility Group B (TcHMGB) can act as an inflammatory mediator on mammalian cells},
  author={Pamela Cribb and Virginia Gabriela Perdomo and Victoria Lucia Alonso and Romina Manarin and Jorge A Barrios-Pay{\'a}n and Brenda Marquina-Castillo and Luis Tavernelli and Rogelio E Hern{\'a}ndez-Pando},
  booktitle={PLoS neglected tropical diseases},
  year={2017}
}
BACKGROUND High Mobility Group B (HMGB) proteins are nuclear architectural factors involved in chromatin remodeling and important nuclear events. HMGBs also play key roles outside the cell acting as alarmins or Damage-associated Molecular Patterns (DAMPs). In response to a danger signal these proteins act as immune mediators in the extracellular milieu. Moreover, these molecules play a central role in the pathogenesis of many autoimmune and both infectious and sterile inflammatory chronic… CONTINUE READING
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