Trypanosoma cruzi 175-kDa protein tyrosine phosphorylation is associated with host cell invasion.

@article{Favoreto1998TrypanosomaC1,
  title={Trypanosoma cruzi 175-kDa protein tyrosine phosphorylation is associated with host cell invasion.},
  author={S. Favoreto and M. L. Dorta and N. Yoshida},
  journal={Experimental parasitology},
  year={1998},
  volume={89 2},
  pages={
          188-94
        }
}
We examined the requirement of Tropanosoma cruzi protein tyrosine phosphorylation for parasite entry into mammalian cells and analyzed the profile of phosphorylated proteins in infective trypomastigotes. Treatment of metacyclic or tissue culture trypomastigotes with genistein, an inhibitor of protein tyrosine kinase activity, significantly inhibited invasion of cultured HeLa cells. A soluble factor, contained in HeLa cell extract and absent in the extract ot T. cruzi-resistant K562 cells… Expand
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