Trypanosoma cruzi: in vitro morphological alterations induced by actinomycin D.

Abstract

Actinomycin (ActD) is an antibiotic that binds DNA, preventing transcription. When a Trypanosoma cruzi infection in mice is treated with this drug, the parasite loses its ability to multiply, enabling protection. In this study, axenic cultured T. cruzi parasites were exposed to different concentrations of ActD (10, 20, and 50 microg/ml), all of them being… (More)

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@article{Valle2003TrypanosomaCI, title={Trypanosoma cruzi: in vitro morphological alterations induced by actinomycin D.}, author={T{\^a}nia Zaverucha do Valle and K{\'a}tia da Silva Calabrese and Suzana C{\^o}rte-Real and Wagner C Baetas and Sylvio Celso Gonçalves da Costa}, journal={Pharmacology}, year={2003}, volume={67 2}, pages={55-8} }