Trypanosoma brucei spliced leader RNA maturation by the cap 1 2'-O-ribose methyltransferase and SLA1 H/ACA snoRNA pseudouridine synthase complex.

@article{Zamudio2009TrypanosomaBS,
  title={Trypanosoma brucei spliced leader RNA maturation by the cap 1 2'-O-ribose methyltransferase and SLA1 H/ACA snoRNA pseudouridine synthase complex.},
  author={Jesse R. Zamudio and Bidyottam Mittra and Arnab Chattopadhyay and James Akira Wohlschlegel and Nancy R. Sturm and David Alexander Campbell},
  journal={Molecular and cellular biology},
  year={2009},
  volume={29 5},
  pages={
          1202-11
        }
}
Kinetoplastid flagellates attach a 39-nucleotide spliced leader (SL) upstream of protein-coding regions in polycistronic RNA precursors through trans splicing. SL modifications include cap 2'-O-ribose methylation of the first four nucleotides and pseudouridine (psi) formation at uracil 28. In Trypanosoma brucei, TbMTr1 performs 2'-O-ribose methylation of the first transcribed nucleotide, or cap 1. We report the characterization of an SL RNA processing complex with TbMTr1 and the SLA1 H/ACA… CONTINUE READING

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