Trypanosoma brucei mitochondrial CR4 gene encodes an extensively edited mRNA with completely edited sequence only in bloodstream forms.

@article{Corell1994TrypanosomaBM,
  title={Trypanosoma brucei mitochondrial CR4 gene encodes an extensively edited mRNA with completely edited sequence only in bloodstream forms.},
  author={Robert W. Corell and Peter J. Myler and Kenneth Stuart},
  journal={Molecular and biochemical parasitology},
  year={1994},
  volume={64 1},
  pages={
          65-74
        }
}
Several kinetoplastid mitochondrial genes cannot be expressed without RNA editing of their transcripts to create a functional open reading frame. We have examined one such mitochondrial gene, CR4, in Trypanosoma brucei EATRO164 and find extensive editing of transcripts in both bloodstream and procyclic life cycle stages. However, a consensus edited sequence for the entire mRNA occurs only in the bloodstream stage. The unedited CR4 transcript is 283 nucleotides in length, not including the poly… CONTINUE READING

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