Trypanosoma brucei gambiense Type 1 populations from human patients are clonal and display geographical genetic differentiation.

@article{Morrison2008TrypanosomaBG,
  title={Trypanosoma brucei gambiense Type 1 populations from human patients are clonal and display geographical genetic differentiation.},
  author={Liam J. Morrison and Andy Tait and G Mccormack and Lindsay Sweeney and Alana Black and Philippe Truc and A C L{\'e}kan{\'e} Likeufack and Charles M. R. Turner and Annette MacLeod},
  journal={Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases},
  year={2008},
  volume={8 6},
  pages={847-54}
}
We have rigorously tested the hypothesis that Trypanosoma brucei gambiense Type 1 is composed of genetically homogenous populations by examining the parasite population present in Human African Trypanosomiasis (HAT) patients from the Democratic Republic of Congo (DRC) and Cameroon (CAM). We amplified eight microsatellite markers by PCR directly from blood spots on FTA filters, thereby avoiding the significant parasite selection inherent in the traditional isolation techniques of rodent… CONTINUE READING
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