Trypanosoma brucei brucei induces alteration in the head proteome of the tsetse fly vector Glossina palpalis gambiensis

@article{Lefvre2007TrypanosomaBB,
  title={Trypanosoma brucei brucei induces alteration in the head proteome of the tsetse fly vector Glossina palpalis gambiensis},
  author={Thierry Lef{\`e}vre and Fr{\'e}d{\'e}ric Thomas and Sophie Ravel and Delphine Patrel and Lionel Renault and Laure Le Bourligu and Gérard Cuny and David G. Biron},
  journal={Insect Molecular Biology},
  year={2007},
  volume={16}
}
Parasitic manipulations of host behaviour are known from a wide range of host–parasite associations. However, the understanding of these phenomena is far from complete and detailed investigation of their proximate causes is needed. Many studies report behavioural modifications, such as altered feeding rates in tsetse fly (Glossina) infected with the mature transmissible stage (i.e. metacyclic) of the trypanosomes. Here, bidimensional (2D) gel electrophoresis and mass spectrometry were employed… 
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This review describes the proteomic approaches that have been used to investigate diverse biological questions about arthropod vectors, including the interplay between vectors and pathogens, and identifies proteins and biochemical pathways that may be involved in molecular crosstalk in BFA‐pathogen associations.
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References

SHOWING 1-10 OF 82 REFERENCES
Malaria Plasmodium agent induces alteration in the head proteome of their Anopheles mosquito host
TLDR
2‐D DIGE coupled with MS was employed to analyse and compare the head proteome of mosquitoes infected with the malarial parasite, and results indicate an altered energy metabolism in the head of sporozoite‐infected mosquitoes.
Monitoring the developmental status of Trypanosoma brucei gambiense in the tsetse fly by means of PCR analysis of anal and saliva drops.
‘Suicide’ of crickets harbouring hairworms: a proteomics investigation
TLDR
Proteomics tools are used to identify the biochemical alterations that occur in the head of the cricket Nemobius sylvestris when it is driven to water by the hairworm Paragordius tricuspidatus and it is found that the parasite produces molecules from the Wnt family that may act directly on the development of the central nervous system (CNS).
Manipulation of medically important insect vectors by their parasites.
  • H. Hurd
  • Biology
    Annual review of entomology
  • 2003
TLDR
This review examines empirical, experimental, and field-based evidence to evaluate examples of changes in vector behavior and physiology that might be construed to be manipulative.
Do distantly related parasites rely on the same proximate factors to alter the behaviour of their hosts?
TLDR
By studying and comparing the brains of infected G. insensibilis and G. pulex with proteomics tools, some of the proximate causes involved in the parasite-induced alterations of host behaviour for each system are elucidated.
Distribution and attachment of Trypanosoma (Nannomonas) congolense in the proximal part of the proboscis of Glossina morsitans morsitans.
The distribution and attachment of Trypanosoma congolense were investigated in the proximal part of the proboscis of Glossina m. morsitans. In the food canal, epimastigotes and trypomastigotes formed…
Behavioural manipulation in a grasshopper harbouring hairworm: a proteomics approach
TLDR
The findings suggest that the adult worm alters the normal functions of the grasshopper's central nervous system (CNS) by producing certain ‘effective’ molecules, which support the hypothesis that host behavioural changes are mediated by a mix of direct and indirect chemical manipulation.
Feeding behaviour of Glossina morsitans morsitans infected with Trypanosoma vivax, T. congolense or T. brucei
TLDR
Evidence was found to suggest that the rosettes of T. vivax and T. brucei parasites in the salivary glands, did not significantly alter the feeding behaviour of the vector.
Feeding behaviour of pathogen-infected vectors
TLDR
In several parasite–vector systems, flight ability, fecundity or gonotrophic concordance of vectors, are affected by parasites and in some cases parasites cause well-documented pathogenic effects.
The effects of trypanosomatids on insects.
...
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