Trypanosoma brucei brucei induces alteration in the head proteome of the tsetse fly vector Glossina palpalis gambiensis

  title={Trypanosoma brucei brucei induces alteration in the head proteome of the tsetse fly vector Glossina palpalis gambiensis},
  author={Thierry Lef{\`e}vre and Fr{\'e}d{\'e}ric Thomas and Sophie Ravel and Delphine Patrel and Lionel Renault and Laure Le Bourligu and Gérard Cuny and David G. Biron},
  journal={Insect Molecular Biology},
Parasitic manipulations of host behaviour are known from a wide range of host–parasite associations. However, the understanding of these phenomena is far from complete and detailed investigation of their proximate causes is needed. Many studies report behavioural modifications, such as altered feeding rates in tsetse fly (Glossina) infected with the mature transmissible stage (i.e. metacyclic) of the trypanosomes. Here, bidimensional (2D) gel electrophoresis and mass spectrometry were employed… 
Molecular characterization of tsetse’s proboscis and its response to Trypanosoma congolense infection
Results suggest that PB is a muscular organ with chemosensory and mechanOSensory capabilities and the mechanoreceptors may be point of PB-trypanosomes interactions.
Tsetse flies, trypanosomes, humans and animals: what is proteomics revealing about their crosstalks?
Proteomics studies performed on African trypanosomes and on the interactions with their vector and mammalian hosts are summarized and the interest of pathogenoproteomics is argued about.
Proteomics and African Trypanosomes: Shedding New Light on Host–Vector–Parasite Interactions and Impact on Control Methods
The interest of proteomics to characterise trypanosomes–hosts interactions is presented, a synthetic review of proteomic studies performed on the parasite and its respective hosts, a discussion on the contributions and pitfalls of using diverse proteomics tools and a projection of new conceptual approaches to accurately decipher insect vector–trypanosome–mammalian host interactions are presented.
A molecular war: convergent and ontogenetic evidence for adaptive host manipulation in related parasites infecting divergent hosts
Proteins involved in energy generation/mobilization were dysregulated, corroborating reports of erratic/hyperactive behaviour in infected hosts and downregulation of CamKII and associated proteins suggest manipulation of memory also contributes to the behavioural shift.
Update on the proteomics of major arthropod vectors of human and animal pathogens
This review describes the proteomic approaches that have been used to investigate diverse biological questions about arthropod vectors, including the interplay between vectors and pathogens, and identifies proteins and biochemical pathways that may be involved in molecular crosstalk in BFA‐pathogen associations.
Climbing the walls : behavioural manipulation of insects by baculoviruses
It is hypothesized that ptp-induced hyperactivity is an evolutionarily conserved strategy of group I NPVs to manipulate host behaviour and the involvement of the protein tyrosine phosphatase (ptp) gene from the baculovirus Autographa californica multiple nucleopolyhedrovirus (AcMNPV) in the induction of hyperactivity of the beet armyworm Spodoptera exigua was studied.


Malaria Plasmodium agent induces alteration in the head proteome of their Anopheles mosquito host
2‐D DIGE coupled with MS was employed to analyse and compare the head proteome of mosquitoes infected with the malarial parasite, and results indicate an altered energy metabolism in the head of sporozoite‐infected mosquitoes.
‘Suicide’ of crickets harbouring hairworms: a proteomics investigation
Proteomics tools are used to identify the biochemical alterations that occur in the head of the cricket Nemobius sylvestris when it is driven to water by the hairworm Paragordius tricuspidatus and it is found that the parasite produces molecules from the Wnt family that may act directly on the development of the central nervous system (CNS).
Manipulation of medically important insect vectors by their parasites.
  • H. Hurd
  • Biology
    Annual review of entomology
  • 2003
This review examines empirical, experimental, and field-based evidence to evaluate examples of changes in vector behavior and physiology that might be construed to be manipulative.
Do distantly related parasites rely on the same proximate factors to alter the behaviour of their hosts?
By studying and comparing the brains of infected G. insensibilis and G. pulex with proteomics tools, some of the proximate causes involved in the parasite-induced alterations of host behaviour for each system are elucidated.
Distribution and attachment of Trypanosoma (Nannomonas) congolense in the proximal part of the proboscis of Glossina morsitans morsitans.
The distribution and attachment of Trypanosoma congolense were investigated in the proximal part of the proboscis of Glossina m. morsitans. In the food canal, epimastigotes and trypomastigotes formed
Behavioural manipulation in a grasshopper harbouring hairworm: a proteomics approach
The findings suggest that the adult worm alters the normal functions of the grasshopper's central nervous system (CNS) by producing certain ‘effective’ molecules, which support the hypothesis that host behavioural changes are mediated by a mix of direct and indirect chemical manipulation.
Feeding behaviour of Glossina morsitans morsitans infected with Trypanosoma vivax, T. congolense or T. brucei
Evidence was found to suggest that the rosettes of T. vivax and T. brucei parasites in the salivary glands, did not significantly alter the feeding behaviour of the vector.
Feeding behaviour of pathogen-infected vectors
In several parasite–vector systems, flight ability, fecundity or gonotrophic concordance of vectors, are affected by parasites and in some cases parasites cause well-documented pathogenic effects.
The effects of trypanosomatids on insects.