Trypanosoma brucei TbIF1 inhibits the essential F1-ATPase in the infectious form of the parasite

@inproceedings{Panicucci2017TrypanosomaBT,
  title={Trypanosoma brucei TbIF1 inhibits the essential F1-ATPase in the infectious form of the parasite},
  author={Brian Panicucci and Ondrej Gahura and Alena Z{\'i}kov{\'a}},
  booktitle={PLoS neglected tropical diseases},
  year={2017}
}
The mitochondrial (mt) FoF1-ATP synthase of the digenetic parasite, Trypanosoma brucei, generates ATP during the insect procyclic form (PF), but becomes a perpetual consumer of ATP in the mammalian bloodstream form (BF), which lacks a canonical respiratory chain. This unconventional dependence on FoF1-ATPase is required to maintain the essential mt membrane potential (Δψm). Normally, ATP hydrolysis by this rotary molecular motor is restricted to when eukaryotic cells experience sporadic hypoxic… CONTINUE READING
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