Trypanosoma brucei: expression of multiple purine transporters prevents the development of allopurinol resistance.

@article{Natto2005TrypanosomaBE,
  title={Trypanosoma brucei: expression of multiple purine transporters prevents the development of allopurinol resistance.},
  author={Manal J. Natto and Lynsey J M Wallace and Denise Candlish and Mohammed I. Al-Salabi and Shona E Coutts and Harry P de Koning},
  journal={Experimental parasitology},
  year={2005},
  volume={109 2},
  pages={80-6}
}
Allopurinol is a hypoxanthine analogue used to treat Leishmania infections that also displays activity against the related parasite Trypanosoma brucei. We have investigated the ease by which resistance to this drug is established in Trypanosoma brucei brucei and correlated this to the mechanisms by which it is accumulated by the parasite. Long-term exposure of procyclic T. b. brucei to 3mM allopurinol did not induce resistance. This appears to be related to the fact that allopurinol was taken… CONTINUE READING