Trypanosoma brucei: constitutive activity of the VSG and procyclin gene promoters.

@article{Pays1990TrypanosomaBC,
  title={Trypanosoma brucei: constitutive activity of the VSG and procyclin gene promoters.},
  author={E. Pays and H Coquelet and Patricia Tebabi and Annette Pays and Donna Jefferies and M. Steinert and Eberhardt Koenig and Richard O. Williams and Isabel Roditi},
  journal={The EMBO journal},
  year={1990},
  volume={9 10},
  pages={3145-51}
}
The variant surface glycoprotein (VSG) and procyclin are the major surface proteins of the bloodstream and procyclic stages, respectively, of Trypanosoma brucei. The promoter regions of the VSG and procyclin gene transcription units could be mapped thanks to the specific enrichment of initial transcripts that occurs following UV irradiation. Whereas the VSG gene is 45 kb distant from its promoter, procyclin genes are located immediately downstream. We show, by run-on assays on isolated nuclei… CONTINUE READING