Trypanocidal bisbenzylisoquinoline alkaloids are inhibitors of trypanothione reductase.

@article{Fournet1998TrypanocidalBA,
  title={Trypanocidal bisbenzylisoquinoline alkaloids are inhibitors of trypanothione reductase.},
  author={Alain Fournet and Alba Inchausti and Gloria Yaluff and Antonieta Rojas de Arias and H{\'e}l{\`e}ne Guinaudeau and Jean -Noel Bruneton and Mark A. Breidenbach and P. Andrew Karplus and Carlos Faerman},
  journal={Journal of enzyme inhibition},
  year={1998},
  volume={13 1},
  pages={1-9}
}
Eleven bisbenzylisoquinoline (BBIQ) alkaloids were studied for in vitro trypanocidal activity against trypomastigote forms of the Y strain of Trypanosoma cruzi. The inhibitory activity of these compounds against trypanothione reductase (TR), a target enzyme for chemotherapy against Chagas disease, was also studied. Six BBIQ alkaloids (antioquine… CONTINUE READING