Corpus ID: 24024658

Trypanocidal activity of bergenin, the major constituent of Flueggea virosa, on Trypanosoma brucei.

  title={Trypanocidal activity of bergenin, the major constituent of Flueggea virosa, on Trypanosoma brucei.},
  author={Barth{\'e}l{\'e}my Nyass{\'e} and J Nono and Bonaventure Sonk{\'e} and Colette Denier and Camile Fontaine},
  journal={Die Pharmazie},
  volume={59 6},
The presence of bergenin in substantial amounts in the methanol leaves extract of Flueggea virosa (Euphorbiaceae) was established as a strong chemotaxomic point of differentiation between Flueggea virosa and Securinega virosa. Bergenin showed an inhibitory effect on the growth of the bloodstream form of Trypanosoma brucei with an IC50 value of 1 microM. 
Antimalarial activity and safety assessment of Flueggea virosa leaves and its major constituent with special emphasis on their mode of action.
Bergenin exhibited a moderate antimalarial activity against P. berghei and also ameliorated parasite induced systemic inflammation in host (mice) and safe toxicity profile elucidated through in vitro cytotoxicity and in silico ADME/T predications evidently suggest that bergenin possess drug like properties.
Antimalarial activity of crude extracts from nine African medicinal plants.
All the plants tested displayed a low cytotoxicity on THP1 cells, and the highest antiplasmodial activity was found for the MeOH/H(2)O leaves extract of Flueggea virosa.
Evaluation of in vitro and in vivo antileishmanial potential of bergenin rich Bergenia ligulata (Wall.) Engl. root extract against visceral leishmaniasis in inbred BALB/c mice through immunomodulation
  • R. Kaur, S. Kaur
  • Biology, Medicine
    Journal of traditional and complementary medicine
  • 2018
The current study revealed the significant antileishmanial and immunomodulatory properties of this plant extract against murine visceral leishmaniasis.
Antimalarial activity of some plants traditionally used in treatment of malaria in Kwale district of Kenya.
Results indicate that there is potential for isolation of a lead compound from the extracts of theFive medicinal plant species used for treatment of malaria in traditional/cultural health systems of Kwale people in Kenya and for their cytotoxic effects.
A comprehensive review on bergenin, a potential hepatoprotective and antioxidative phytoconstituent
Bergenin (1) is a c-glucoside of 4-O-methylgallic acid that has been reported to occur naturally in several genera. it exhibits a wide array of biological activities and also in several cases is
Phytochemical Screening, Acute Toxicity and Analgesic Properties of Aqueous Extract of Flueggea virosa's Root in Rats
The aqueous extract of the Flueggea virosa's root produces modest yield of extract and possesses potent phytochemicals, some measure of acute safety and significant analgesic properties.
Identification and antiproliferative activity evaluation of a series of triterpenoids isolated from Flueggea virosa (Roxb. ex Willd.).
Problem statement: Medicinal plants derived anticancer were now being subjects of many research groups especially, the secondary metabolite triterpenoids trees which had enormous potential to inspire
Diversity, pharmacology and synthesis of bergenin and its derivatives: potential materials for therapeutic usages.
This comprehensive review provides information on the potentiality of bergenin and its derivatives for therapeutic usages in herbal and Ayurvedic formulations until 2013.
Antimalarial Plants Used across Kenyan Communities
  • Timothy Omara
  • Biology, Medicine
    Evidence-based complementary and alternative medicine : eCAM
  • 2020
The study highlighted a rich diversity of indigenous antimalarial plants with equally divergent herbal remedy preparation and use pattern in Kenya, which could be potential sources of antimalaria remedies.
Investigation of some medicinal plants traditionally used for treatment of malaria in Kenya as potential sources of antimalarial drugs.
An analysis of ethnopharmacological publications on antimalarial therapies from some Kenyan medicinal plants shows that quinine and artemisinin came originally from indigenous medical systems and Chinese ancestral treatments, respectively.