Trypanocidal activity of a new diterpene from Casearia sylvestris var. lingua.

  title={Trypanocidal activity of a new diterpene from Casearia sylvestris var. lingua.},
  author={Laila Salmen Esp{\'i}ndola and Jos{\'e} Rossy e Vasconcelos J{\'u}nior and Mariana Laundry de Mesquita and Patrick Marqui{\'e} and Jos{\'e} Elias de Paula and Lengo Mambu and Jaime M. Santana},
  journal={Planta medica},
  volume={70 11},
Bioassay-guided fractionation of the hexanic root bark extract of Casearia sylvestris var. lingua led to the isolation of a new clerodane diterpene, whose structure was elucidated as rel-(2 S,5 R,6 R,8 S,9 S,10 R,18 S,19 R)-19-acetoxy-18,19-epoxy-6-hydroxy-18-butanoyloxy-2-(2-methylbutanoyloxy)cleroda-3,13(16), 14-triene by spectroscopic means, including 1D and 2D NMR analyses. This compound showed pronounced activity on Trypanosoma cruzi, the casual agent of Chagas' disease, with minimal… CONTINUE READING

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