TrxR1 as a potent regulator of the Nrf2-Keap1 response system.

@article{Cebula2015TrxR1AA,
  title={TrxR1 as a potent regulator of the Nrf2-Keap1 response system.},
  author={M. Cebula and Edward E Schmidt and Elias S. J. Arn{\'e}r},
  journal={Antioxidants & redox signaling},
  year={2015},
  volume={23 10},
  pages={
          823-53
        }
}
SIGNIFICANCE All cells must maintain a balance between oxidants and reductants, while allowing for fluctuations in redox states triggered by signaling, altered metabolic flow, or extracellular stimuli. Furthermore, they must be able to rapidly sense and react to various challenges that would disrupt the redox homeostasis. RECENT ADVANCES Many studies have identified Keap1 as a key sensor for oxidative or electrophilic stress, with modification of Keap1 by oxidation or electrophiles triggering… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 43 CITATIONS

Nature and Implications of Oxidative and Nitrosative Stresses in Autoimmune Hepatitis

  • Digestive Diseases and Sciences
  • 2016
VIEW 11 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

The evolving versatility of selenium in biology.

  • Antioxidants & redox signaling
  • 2015
VIEW 4 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Curcuminoid WZ35 synergize with cisplatin by inducing ROS production and inhibiting TrxR1 activity in gastric cancer cells

  • Journal of experimental & clinical cancer research : CR
  • 2019
VIEW 1 EXCERPT
CITES BACKGROUND