Truncation variants of peptides isolated from MHC class II molecules suggest sequence motifs

@article{Rudensky1992TruncationVO,
  title={Truncation variants of peptides isolated from MHC class II molecules suggest sequence motifs},
  author={Alexander Yu. Rudensky and Paula Preston-Hurlburt and Basel K. al-Ramadi and Jonathan B. Rothbard and Charles A. Janeway},
  journal={Nature},
  year={1992},
  volume={359},
  pages={429-431}
}
T CELLS recognize foreign protein antigens in the form of peptide fragments bound tightly to the outer aspect of molecules encoded by the major histocompatibility complex (MHC). Most of the amino-acid differences that distinguish MHC allelic variants line the peptide-binding cleft, and different allelic forms of MHC molecules bind distinct peptides1,2. It has been demonstrated that peptide-binding to MHC class I involves anchor residues in certain positions and that antigenic peptides… CONTINUE READING

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