Truncation of the carboxyl-terminal region of the rat parathyroid hormone (PTH)/PTH-related peptide receptor enhances PTH stimulation of adenylyl cyclase but not phospholipase C.

@article{IidaKlein1995TruncationOT,
  title={Truncation of the carboxyl-terminal region of the rat parathyroid hormone (PTH)/PTH-related peptide receptor enhances PTH stimulation of adenylyl cyclase but not phospholipase C.},
  author={Akiko Iida-Klein and Jianping Guo and Lily Y. Xie and Harald W Jueppner and John T. Potts and Henry M. Kronenberg and F. Richard Bringhurst and Abdul. B. Abou-Samra and Gino V. Segre},
  journal={The Journal of biological chemistry},
  year={1995},
  volume={270 15},
  pages={
          8458-65
        }
}
The functional role of the rat parathyroid hormone(PTH)/PTH-related peptide (PTHrP) receptor's carboxyl-terminal region was characterized by comparing the binding and signaling properties of receptors that have 78 and 111 amino acid deletions (R513 and R480, respectively), with those of the 591-amino acid wild-type (WT) receptor. R480 and R513 have 4- and 1.5-fold lower apparent Kd values for rat PTH-(1-34) (rPTH), compared with the WT receptor (WT, 1.81 +/- 0.19 nM; R513, 1.24 +/- 0.12 nM… CONTINUE READING
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