Truncation of CDK5 activator p35 induces intensive phosphorylation of Ser202/Thr205 of human tau.

@article{Hashiguchi2002TruncationOC,
  title={Truncation of CDK5 activator p35 induces intensive phosphorylation of Ser202/Thr205 of human tau.},
  author={Mitsuko Hashiguchi and Taro L. Saito and Shin-ichi Hisanaga and Toshio Hashiguchi},
  journal={The Journal of biological chemistry},
  year={2002},
  volume={277 46},
  pages={44525-30}
}
Hyperphosphorylated tau is a major component of neurofibrillary tangles, one of the hallmarks of Alzheimer's disease. CDK5 is a kinase that phosphorylates the tau protein, and its endogenous activator, p35, regulates its activity. Recently, calpain was found to digest p35 to its truncated product, p25. Several lines of evidence suggest that p25-CDK5 has much more powerful kinase activity and that it may cause abnormal hyperphosphorylation of tau. In this study, we have examined the kinetic… CONTINUE READING