Truncated thioredoxin (Trx80) induces production of interleukin-12 and enhances CD14 expression in human monocytes.

@article{Pekkari2001TruncatedT,
  title={Truncated thioredoxin (Trx80) induces production of interleukin-12 and enhances CD14 expression in human monocytes.},
  author={Klas Pekkari and Javier Avila-Cari{\~n}o and Asa Bengtsson and Ramanathan Gurunath and A Scheynius and Arne Holmgren},
  journal={Blood},
  year={2001},
  volume={97 10},
  pages={3184-90}
}
Human thioredoxin (Trx) is the major 12-kd cellular disulfide-reductase that on secretion acts as a cocytokine with several interleukins. Truncated Trx with the 80 N-terminal residues (Trx80), also present in plasma, was by itself a mitogenic cytokine for human peripheral blood mononuclear cells (PBMC). This study investigated which cells in PBMC are targets of recombinant Trx80. Purified human CD14(+) monocytes, but not B or T cells, in a synthetic medium were activated to differentiation by… CONTINUE READING
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