Truncated mouse adenomatous polyposis coli reduces connexin32 content and increases matrilysin secretion from Paneth cells.

@article{Husy2004TruncatedMA,
  title={Truncated mouse adenomatous polyposis coli reduces connexin32 content and increases matrilysin secretion from Paneth cells.},
  author={Trine Hus\oy and Hege Benedikte \Olst\orn and Helle Katrine Knutsen and Else Marit L\oberg and V{\'e}ronique Cruciani and Svein-Ole Mikalsen and Ingeborg L\ostegaard Goverud and Jan Alexander},
  journal={European journal of cancer},
  year={2004},
  volume={40 10},
  pages={1599-603}
}
Heterozygous mutations in adenomatous polyposis coli (APC) is an early event in inheritable and sporadic colon cancer development. We recently found reduced connexin (Cx43) expression in intestinal cell lines with heterozygous Apc mutation. In this study we investigated Cx expression and the role of one mutated Apc allele in epithelia of multiple intestinal neoplasia (Min) mouse intestines by immunohistochemistry. Cx43 was not expressed in intestinal epithelia of Min and wild-type mice. Cx32… CONTINUE READING