Truncated hemoglobin GlbO from Mycobacterium leprae alleviates nitric oxide toxicity.

@article{Fabozzi2006TruncatedHG,
  title={Truncated hemoglobin GlbO from Mycobacterium leprae alleviates nitric oxide toxicity.},
  author={Giulia Fabozzi and Paolo Ascenzi and Simona Di Renzi and Paolo Visca},
  journal={Microbial pathogenesis},
  year={2006},
  volume={40 5},
  pages={211-20}
}
As a consequence of reductive genome evolution, the obligate intracellular pathogen Mycobacterium leprae has minimized the repertoire of genes implicated in defense against reactive oxygen and nitrogen species. Genes for multiple hemoglobin types coexist in mycobacterial genomes, but M. leprae has retained only glbO, encoding a group-II truncated hemoglobin. Mycobacterium tuberculosis GlbO has been involved in oxygen transfer and respiration during hypoxia, but a role in protection from nitric… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 10 extracted citations

Haemoglobins of Mycobacteria: structural features and biological functions.

Advances in microbial physiology • 2013
View 8 Excerpts
Highly Influenced

Hemoglobin: A Nitric-Oxide Dioxygenase

Scientifica • 2012
View 5 Excerpts
Highly Influenced

The diversity of 2/2 (truncated) globins.

Advances in microbial physiology • 2013
View 1 Excerpt

Similar Papers

Loading similar papers…