Truncated and chimeric HMGI-C genes induce neoplastic transformation of NIH3T3 murine fibroblasts

@article{Fedele1998TruncatedAC,
  title={Truncated and chimeric HMGI-C genes induce neoplastic transformation of NIH3T3 murine fibroblasts},
  author={Monica Fedele and Maria Teresa Berlingieri and Stefania Scala and Lorenzo Chiariotti and Giuseppe Viglietto and Volkhard Rippel and Jorn Bullerdiek and Massimo Santoro and Alfredo Fusco},
  journal={Oncogene},
  year={1998},
  volume={17},
  pages={413-418}
}
Overexpression of the high mobility group I (HMGI) proteins is often associated with the malignant phenotype. Moreover, many benign human tumors, mainly of mesenchymal origin, are characterized by rearrangements of the HMGI-C gene. In most cases, HMGI-C alterations involve breaks within the third intron of the gene resulting in aberrant transcripts carrying exons from 1–3, which encode the three DNA binding domains, fused to ectopic sequences. Here, we show that the expression of a truncated… CONTINUE READING
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