Truncated TrkB-T1 mediates neurotrophin-evoked calcium signalling in glia cells

@article{Rose2003TruncatedTM,
  title={Truncated TrkB-T1 mediates neurotrophin-evoked calcium signalling in glia cells},
  author={Christine R. Rose and Robert Blum and Bruno Pichler and Alexandra Lepier and Karl W. Kafitz and Arthur Konnerth},
  journal={Nature},
  year={2003},
  volume={426},
  pages={74-78}
}
The neurotrophin receptor TrkB is essential for normal function of the mammalian brain. It is expressed in three splice variants. Full-length receptors (TrkBFL) possess an intracellular tyrosine kinase domain and are considered as those TrkB receptors that mediate the crucial effects of brain-derived neurotrophic factor (BDNF) or neurotrophin 4/5 (NT-4/5). By contrast, truncated receptors (TrkB-T1 and TrkB-T2) lack tyrosine kinase activity and have not been reported to elicit rapid… Expand
Truncated TrkB: beyond a dominant negative receptor.
  • B. Fenner
  • Chemistry, Medicine
  • Cytokine & growth factor reviews
  • 2012
TLDR
BDNF activates trkB receptors to regulate neuronal survival, differentiation, and proliferation, and regulates Rho GTPase signaling, and modifies cytoskeletal structures. Expand
Excitotoxicity Downregulates TrkB.FL Signaling and Upregulates the Neuroprotective Truncated TrkB Receptors in Cultured Hippocampal and Striatal Neurons
TLDR
The results indicate that BDNF protects hippocampal neurons by two distinct mechanisms: through the neurotrophic effects of TrkB.FL receptors and by activation of Tr.T receptors coupled to inhibition of the excitotoxic signaling. Expand
Truncated TrkB receptor-induced outgrowth of dendritic filopodia involves the p75 neurotrophin receptor
TLDR
It is shown that overexpression of Tr.T1 in hippocampal neurons induces the formation of dendritic filopodia, which are known precursors of synaptic spines, and proposes a novel signalling pathway initiated by neurotrophin-independent extracellular or intramembrane interaction of TrkB.FL. Expand
The neurotrophin receptor TrkB is colocalized to mitochondrial membranes.
TLDR
It is verified that a truncated isoform of TrkB is present in both, brain and muscle mitochondria, and full-lengthtrkB is additionally present in brain mitochondaria, which implies that neurotrophins can be stored in mitochondria and possibly act as signalling molecules on mitochondria. Expand
Presence of Functional Neurotrophin TrkB Receptors in the Rat Superior Cervical Ganglion
TLDR
It is demonstrated that SCG neurons express functional TrkA and TrkB-Fl receptors, which may contribute to the differential modulation of synaptic transmission and long-term synaptic plasticity. Expand
Endogenous Truncated TrkB.T1 Receptor Regulates Neuronal Complexity and TrkB Kinase Receptor Function In Vivo
TLDR
The results suggest that, at the physiological level, Tr.T1 receptors are important regulators of TrkB.FL signaling in vivo and selectively affects dendrite complexity of certain neuronal populations. Expand
Neurotrophin receptors TrkB.T1 and p75NTR cooperate in modulating both functional and structural plasticity in mature hippocampal neurons
TLDR
It is demonstrated that TrkB.T1 regulates the function and the structure of mature pyramidal neurons and p75NTR receptor signaling systems might be cross‐linked, and played an important role in modulating dendritic architecture and synaptic plasticity in the adult rodent hippocampus. Expand
A small molecule TrkB/TrkC neurotrophin receptor co-activator with distinctive effects on neuronal survival and process outgrowth
TLDR
LM22B-10 may constitute a new tool for the study of TrkB and TrkC signaling and their interactions with p75(NTR), and provides groundwork for the development of ligands that stimulate unique combinations of Trk receptors and activity patterns for application to selected neuronal populations and deficits present in various disease states. Expand
In vivo evidence that truncated trkB.T1 participates in nociception
TLDR
The results suggest that trkB.T1 up-regulation following antiretroviral treatment and tissue inflammation participates in the development and maintenance of nocifensive behavior and may represent a novel therapeutic target for pain treatment. Expand
BDNF/TrkB.T1 signaling is a novel mechanism for astrocyte morphological maturation
TLDR
Astrocytes express high levels of BDNF’s receptor, TrkB (in the top 20 of protein-coding transcripts), with nearly exclusive expression of the truncated isoform, Tr.T1 which peaks in expression during astrocyte morphological maturation, indicating a role for functional astroCyte maturation via BDNF/TrkB. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 36 REFERENCES
Signal Transduction Mediated by the Truncated trkB Receptor Isoforms, trkB.T1 and trkB.T2
TLDR
Mutational analysis demonstrates that the isoform-specific sequences within the intracellular domains of each receptor are essential for signaling capability, and inhibitor studies suggest that kinases are likely to be involved in the trkB.T1 and tr.T2 signaling pathways. Expand
Neurotrophin-evoked rapid excitation through TrkB receptors
TLDR
The results demonstrate a very rapid excitatory action of neurotrophins, placing them among the most potent endogenous neuro-excitants in the mammalian central nervous system described so far. Expand
Astrocytes in culture express the full-length Trk-B receptor and respond to brain derived neurotrophic factor by changing intracellular calcium levels: effect of ethanol exposure in rats
Although cultured astroglial cells were reported to express exclusively the truncated non-catalytic Trk B receptor for brain-derived neurotrophic factor (BDNF), we detect here, using a sensitiveExpand
BDNF‐activated Sianal Transduction in Rat Cortical Glial Cells
TLDR
The results of these studies demonstrate that a subset of cultured CNS glia respond to BDNF with the activation of conventional signal transduction processes, which most likely involves a relatively small number of gp 145trkB receptors, but involvement of the more abundant truncated trkB receptors cannot be excluded. Expand
Neurotrophin-evoked depolarization requires the sodium channel NaV1.9
TLDR
It is demonstrated that the tetrodotoxin-insensitive sodium channel NaV1.9 underlies the neurotrophin-evoked excitation and a mechanism of ligand-mediated sodium channel activation is revealed. Expand
Neural differentiation promoted by truncated trkC receptors in collaboration with p75(NTR).
TLDR
A phenotypic response to activation of the trkC TK- receptor is identified and a functional interaction with p75(NTR) neurotrophin receptor is demonstrated, indicating there may be multipletrkC receptor-mediated systems guiding neuronal differentiation. Expand
Trk receptors: mediators of neurotrophin action
TLDR
Three-dimensional structures of the Trk receptors, in one instance in association with a neurotrophin, have revealed the structural bases underlying specificity in neurotrophIn signaling, where key intermediates are localized to different membrane compartments. Expand
TTIP is a novel protein that interacts with the truncated T1 TrkB neurotrophin receptor.
  • D. Kryl, P. Barker
  • Biology, Medicine
  • Biochemical and biophysical research communications
  • 2000
TLDR
A protein from 15N neuroblastoma cells that specifically binds the TrkB.T1 isoform is isolated and MALDI MS and MS/MS analysis has revealed that TTIP is a novel protein not yet listed in the current databases. Expand
The neurotrophin receptor p75NTR: novel functions and implications for diseases of the nervous system
TLDR
The p75 neurotrophin receptor (p75NTR), a member of the tumor necrosis factor receptor superfamily, associates with the Nogo receptor, a binding protein for axonal growth inhibitors, and appears to be the transducing subunit of this receptor complex. Expand
trkB, a neural receptor protein-tyrosine kinase: evidence for a full-length and two truncated receptors.
TLDR
An adult rat cerebellar cDNA library in search of novel protein tyrosine-kinase (PTK) cDNAs showed that the trkB gene is expressed predominantly in the brain and that trkB expresses multiple mRNAs, ranging from 0.7 to 9 kb, and hybridization of cerebral mRNAAs with a variety of probes indicates that there are m RNAs encoding truncated trkB receptors. Expand
...
1
2
3
4
...