Truncated Hemoglobin, HbN, Is Post-translationally Modified in Mycobacterium tuberculosis and Modulates Host-Pathogen Interactions during Intracellular Infection*

@article{Arya2013TruncatedHH,
  title={Truncated Hemoglobin, HbN, Is Post-translationally Modified in Mycobacterium tuberculosis and Modulates Host-Pathogen Interactions during Intracellular Infection*},
  author={S. Arya and Deepti Sethi and Sandeep Singh and Mangesh D Hade and Vijender Singh and P. Raju and Sathi Babu Chodisetti and D. Verma and G. C. Varshney and J. Agrewala and K. Dikshit},
  journal={The Journal of Biological Chemistry},
  year={2013},
  volume={288},
  pages={29987 - 29999}
}
Background: Mycobacterium tuberculosis HbN detoxifies nitric oxide and protects its host under nitrosative stress. Results: The HbN remains glycosylated and membrane-localized in M. tuberculosis and modulates host-pathogen interactions. Conclusion: The HbN facilitates intracellular infection and cell survival by evading the immune system of the host. Significance: This study unravels new knowledge about function(s) of HbN in biology and pathogenesis of M. tuberculosis. Mycobacterium… Expand
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