Truncated ALK derived from chromosomal translocation t(2;5)(p23;q35) binds to the SH3 domain of p85-PI3K.

@article{Polgar2005TruncatedAD,
  title={Truncated ALK derived from chromosomal translocation t(2;5)(p23;q35) binds to the SH3 domain of p85-PI3K.},
  author={Doris Polgar and Christina Leisser and Susanne Maier and Stephan Strasser and Beate R{\"u}ger and Markus Dettke and Maya Khorchide and Ingrid Simonitsch and Christa Cerni and Georg Krupitza},
  journal={Mutation research},
  year={2005},
  volume={570 1},
  pages={9-15}
}
The chromosomal translocation t(2;5)(p23;q35) is associated with "Anaplastic large cell lymphomas" (ALCL), a Non Hodgkin Lymphoma occurring in childhood. The fusion of the tyrosine kinase gene-ALK (anaplastic lymphoma kinase) on chromosome 2p23 to the NPM (nucleophosmin/B23) gene on chromosome 5q35 results in a 80 kDa chimeric protein, which activates the "survival" kinase PI3K. However, the binding mechanism between truncated ALK and PI3K is poorly understood. Therefore, we attempted to… CONTINUE READING

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