Corpus ID: 55787743

True prediction by consensus for small sets of cyclooxigenase-2 inhibitors

@article{JulianOniz2003TruePB,
  title={True prediction by consensus for small sets of cyclooxigenase-2 inhibitors},
  author={Jesus Vicente De Julian-Oniz and E. Besal{\'u} and R. Garc{\'i}a-Domenech},
  journal={Indian journal of chemistry. Sect. A: Inorganic, physical, theoretical \& analytical},
  year={2003},
  volume={42},
  pages={1392-1404}
}
A set of 21 previously published COX-2 inhibitors has been analyzed in order to obtain a new paradigm capable of obtaining true predictions of the activity. Overfitting in the models has effectively been prevented even for small training sets. The most significant variables for the prediction of the property have been selected, and outliers have also been easily identified with this approach. Topological indices have been used as descriptors. 

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