True malignant histiocytosis with trisomy 9 following primary mediastinal germ cell tumor.

@article{Suenaga2006TrueMH,
  title={True malignant histiocytosis with trisomy 9 following primary mediastinal germ cell tumor.},
  author={Mitsuhiro Suenaga and Kakushi Matsushita and Nakaaki Kawamata and Toshimasa Kukita and Yuji Hamakawa and Kentaro Gejima and Reiri Onodera and Tetsuo Sato and Akihiko Yamaguchi and Hirosaka Inoue and Kosei Arimura and Naomichi Arima and Hiroki Yoshida and Chuwa Tei},
  journal={Acta haematologica},
  year={2006},
  volume={116 1},
  pages={62-6}
}
A 24-year-old Japanese man was admitted due to bloody phlegm in May 2002. A diagnosis of mediastinal germ cell tumor, mixed type involving seminoma, immature teratoma and embryonal carcinoma, was made by transthoracic needle biopsy. Three months later, his complete blood counts revealed pancytopenia with high fever. Examination of bone marrow revealed increased atypical large histiocytes (5.6%) with hemophagocytosis, and thus, hemophagocytic syndrome related to germ cell tumor was diagnosed. In… CONTINUE READING