True and apparent optogenetic BOLD fMRI signals.

  title={True and apparent optogenetic BOLD fMRI signals.},
  author={Florian Schmid and Lydia Wachsmuth and Franziska Albers and Miriam Schwalm and Albrecht Stroh and Cornelius Faber},
  journal={Magnetic resonance in medicine},
  volume={77 1},
PURPOSE Optogenetic fMRI (ofMRI) is a novel tool in neurophysiology and neuroimaging. The method is prone to light-induced artifacts, two of which were investigated in this study. METHODS ofMRI was performed in rats using two excitatory opsins (ChR2 and C1V1TT ) virally transduced in somatosensory cortex or thalamus. Heat-induced apparent BOLD activation at the site of the optical fiber and stimulation light-induced activation of the visual pathways were investigated, and control experiments… CONTINUE READING
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