Trs20 is required for TRAPP III complex assembly at the PAS and its function in autophagy.

@article{Taussig2014Trs20IR,
  title={Trs20 is required for TRAPP III complex assembly at the PAS and its function in autophagy.},
  author={David Taussig and Zhanna Lipatova and Nava Segev},
  journal={Traffic},
  year={2014},
  volume={15 3},
  pages={327-37}
}
The modular TRAPP complex acts as a guanine-nucleotide exchange factor (GEF) for Ypt/Rab GTPases. Whereas TRAPP I and TRAPP II regulate the exocytic pathway, TRAPP III functions in autophagy. The TRAPP subunit Trs20 is not required for assembly of core TRAPP or its Ypt1 GEF activity. Interestingly, mutations in the human functional ortholog of Trs20, Sedlin, cause spondyloepiphyseal dysplasia tarda (SEDT), a cartilage-specific disorder. We have shown that Trs20 is required for TRAPP II assembly… CONTINUE READING
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