Trps1 haploinsufficiency promotes renal fibrosis by increasing Arkadia expression.

Abstract

Mutations in TRPS1 cause tricho-rhino-pharyngeal syndrome (TRPS). Trps1 is essential for nephron development, acting downstream of Bmp7. Because Bmp7 counteracts epithelial-to-mesenchymal transition (EMT) and reverses chronic renal injury, we examined the function of Trps1 in renal fibrosis. Immunohistochemistry revealed Trps1 expression in proximal tubular… (More)
DOI: 10.1681/ASN.2009121201

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