Trps1 deficiency enlarges the proliferative zone of growth plate cartilage by upregulation of Pthrp.

@article{Nishioka2008Trps1DE,
  title={Trps1 deficiency enlarges the proliferative zone of growth plate cartilage by upregulation of Pthrp.},
  author={Katsuhiro Nishioka and Shunji Itoh and Hiroki Suemoto and Seiji Kanno and Zhibo Gai and Motohisa Kawakatsu and Hiroyuki Tanishima and Yoshifumi Morimoto and Ikuji Hatamura and Munehito Yoshida and Yasuteru Muragaki},
  journal={Bone},
  year={2008},
  volume={43 1},
  pages={
          64-71
        }
}
  • Katsuhiro Nishioka, Shunji Itoh, +8 authors Yasuteru Muragaki
  • Published 2008
  • Biology, Medicine
  • Bone
  • We have reported that elongation of the columnar proliferative zone of long bone growth plates in Trps1-/- mice during the late fetal stage in the previous study [1]. Since expression of Trps1 protein was found to overlap with that of mRNAs for Indian hedgehog (Ihh), PTH/PTHrP receptor (PPR), and PTHrP, we hypothesized that Trps1 may inhibit the hypertrophic differentiation of chondrocytes by interacting with the Ihh/PTHrP feedback loop. To investigate whether Trps1 has a role in this Ihh/PTHrP… CONTINUE READING

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