Trpm4 Gene Invalidation Leads to Cardiac Hypertrophy and Electrophysiological Alterations

  title={Trpm4 Gene Invalidation Leads to Cardiac Hypertrophy and Electrophysiological Alterations},
  author={Marie Demion and J{\'e}r{\^o}me Thireau and M{\'e}lanie Gueffier and A Centr tra Finan and Ziad Khoueiry and C{\'e}cile Cassan and Nicolas Serafini and Franck Aimond and M. Granier and J M Pasqui{\'e} and Pierre Launay and Sylvain Richard},
  booktitle={PloS one},
RATIONALE TRPM4 is a non-selective Ca2+-activated cation channel expressed in the heart, particularly in the atria or conduction tissue. Mutations in the Trpm4 gene were recently associated with several human conduction disorders such as Brugada syndrome. TRPM4 channel has also been implicated at the ventricular level, in inotropism or in arrhythmia genesis due to stresses such as ß-adrenergic stimulation, ischemia-reperfusion, and hypoxia re-oxygenation. However, the physiological role of the… CONTINUE READING
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