Trp53 haploinsufficiency modifies EGFR-driven peripheral nerve sheath tumorigenesis.


Malignant peripheral nerve sheath tumors (MPNSTs) are genetically diverse, aggressive sarcomas that occur sporadically or in association with neurofibromatosis type 1 syndrome. Reduced TP53 gene expression and amplification/overexpression of the epidermal growth factor receptor (EGFR) gene occur in MPNST formation. We focused on determining the… (More)
DOI: 10.1016/j.ajpath.2014.04.006