Trowel: a fast and accurate error correction module for Illumina sequencing reads

  title={Trowel: a fast and accurate error correction module for Illumina sequencing reads},
  author={Eun-Cheon Lim and Jonas M{\"u}ller and J{\"o}rg Hagmann and Stefan R. Henz and Sang-Tae Kim and Detlef Weigel},
  volume={30 22},
MOTIVATION The ability to accurately read the order of nucleotides in DNA and RNA is fundamental for modern biology. Errors in next-generation sequencing can lead to many artifacts, from erroneous genome assemblies to mistaken inferences about RNA editing. Uneven coverage in datasets also contributes to false corrections. RESULT We introduce Trowel, a massively parallelized and highly efficient error correction module for Illumina read data. Trowel both corrects erroneous base calls and… CONTINUE READING
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