Trough plasma concentration of imatinib reflects BCR-ABL kinase inhibitory activity and clinical response in chronic-phase chronic myeloid leukemia: a report from the BINGO study.

@article{Ishikawa2010TroughPC,
  title={Trough plasma concentration of imatinib reflects BCR-ABL kinase inhibitory activity and clinical response in chronic-phase chronic myeloid leukemia: a report from the BINGO study.},
  author={Yuichi Ishikawa and Hitoshi Kiyoi and Keisuke Watanabe and Koichi Miyamura and Yasuyuki Nakano and Kunio Kitamura and Akio Kohno and Isamu Sugiura and Toshiya Yokozawa and Akitoshi Hanamura and Kazuhito Yamamoto and Hiroatsu Iida and Nobuhiko Emi and Ritsuro Suzuki and Kazunori Ohnishi and Tomoki Naoe},
  journal={Cancer science},
  year={2010},
  volume={101 10},
  pages={2186-92}
}
Pharmacokinetic (PK) factors have been suggested to be involved in the unfavorable clinical responses of chronic myeloid leukemia (CML) patients treated with imatinib. The purpose of this study was to clarify prognostic implications of PK factors in CML patients treated with imatinib. The plasma trough (C(min)) level of imatinib and serum α(1)-acid glycoprotein (AGP) level were measured on two different days in 65 CML patients treated with imatinib for more than 12 months. We further examined… CONTINUE READING

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