Troponin and Titin Coordinately Regulate Length-dependent Activation in Skinned Porcine Ventricular Muscle

@article{Terui2008TroponinAT,
  title={Troponin and Titin Coordinately Regulate Length-dependent Activation in Skinned Porcine Ventricular Muscle},
  author={Takako Terui and Munguntsetseg Sodnomtseren and Douchi Matsuba and Jun Udaka and Shin'ichi Ishiwata and Iwao Ohtsuki and Satoshi Kurihara and Norio Fukuda},
  journal={The Journal of General Physiology},
  year={2008},
  volume={131},
  pages={275 - 283}
}
We investigated the molecular mechanism by which troponin (Tn) regulates the Frank-Starling mechanism of the heart. Quasi-complete reconstitution of thin filaments with rabbit fast skeletal Tn (sTn) attenuated length-dependent activation in skinned porcine left ventricular muscle, to a magnitude similar to that observed in rabbit fast skeletal muscle. The rate of force redevelopment increased upon sTn reconstitution at submaximal levels, coupled with an increase in Ca2+ sensitivity of force… CONTINUE READING
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