Troponin T isoform expression in humans. A comparison among normal and failing adult heart, fetal heart, and adult and fetal skeletal muscle.

  title={Troponin T isoform expression in humans. A comparison among normal and failing adult heart, fetal heart, and adult and fetal skeletal muscle.},
  author={Page A. W. Anderson and Nadia N. Malouf and Annette E Oakeley and Edward D. Pagani and Paul D. Allen},
  journal={Circulation research},
  volume={69 5},
The expression of troponin (Tn) T, a thin-filament regulatory protein, was examined in left ventricular myocardium from normal and from failing adult human hearts. The differences in isoform expression between normal and failing myocardium led us to examine the ontogenic expression of TnT in human striated muscle. Left ventricular samples were obtained from patients with severe heart failure undergoing cardiac transplantation and normal adult organ donors. Fetal muscle was obtained from aborted… 

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The slow skeletal muscle troponin T gene is expressed in developing and diseased human heart

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Four full-length cDNAs corresponding to the four native cTnT protein isoforms are cloned and sequenced and expressed in an in vitro transcription and translation system and yielded proteins that comigrate with the native isoforms.

RNA expression of cardiac troponin T isoforms in diseased human skeletal muscle.

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Cardiac Development and in End-Stage Heart Failure

Analyzing right and left ventricular muscle samples from 17 hearts in end-stage heart failure resulting from pulmonary hypertension, ischemic heart disease, or dilated cardiomyopathy concludes that alterations in troponin I isoform content do not therefore contribute to the altered contractile characteristics of the adult failing ventricle.

Rapid purification of mammalian cardiac troponin T and its isoform switching in rat hearts during development.

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  • 1988
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Force-pCa relation and troponin T isoforms of rabbit myocardium.

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Immunological Identification of Five Troponin T Isoforms Reveals an Elaborate Maturational Troponin T Profile in Rabbit Myocardium

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Atrial-natriuretic-factor mRNA is developmentally regulated in heart ventricles and actively expressed in cultured ventricular cardiac muscle cells of rat and human.

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Myosin Isoenzymes in Normal and Hypertrophied Human Ventricular Myocardium

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Changes in Myofibrillar Content and Mg‐ATPase Activity in Ventricular Tissues From Patients with Heart Failure Caused by Coronary Artery Disease, Cardiomyopathy, or Mitral Valve Insufficiency

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Heterogeneity of contractile proteins. A continuum of troponin-tropomyosin expression in mammalian skeletal muscle.

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