Tropomyosins as interpreters of the signalling environment to regulate the local cytoskeleton.

@article{Oneill2008TropomyosinsAI,
  title={Tropomyosins as interpreters of the signalling environment to regulate the local cytoskeleton.},
  author={Geraldine M O'neill and Justine Stehn and Peter W Gunning},
  journal={Seminars in cancer biology},
  year={2008},
  volume={18 1},
  pages={35-44}
}
A key regulator of cell morphology is the actin cytoskeleton and it has long been appreciated that the cytoskeleton is characteristically altered in cancer. Actin is organized into polymeric structures with distinct dynamics which in turn participate in a wide variety of cell processes including adhesion, migration, cell division and apoptosis. Despite displaying an altered actin cytoskeleton, transformed cells retain--and in many cases increase--their ability to adhere, move, divide and… CONTINUE READING