Tropomyosin stabilizes the pointed end of actin filaments by slowing depolymerization.

@article{Broschat1989TropomyosinST,
  title={Tropomyosin stabilizes the pointed end of actin filaments by slowing depolymerization.},
  author={Kay O. Broschat and Annemarie Weber and David R. B. Burgess},
  journal={Biochemistry},
  year={1989},
  volume={28 21},
  pages={
          8501-6
        }
}
Tropomyosin is postulated to confer stability to actin filaments in nonmuscle cells. We have found that a nonmuscle tropomyosin isolated from the intestinal epithelium can directly stabilize actin filaments by slowing depolymerization from the pointed, or slow-growing, filament end. Kinetics of elongation and depolymerization from the pointed end were measured in fluorescence assays using pyrenylactin filaments capped at the barbed end by villin. The initial pointed end depolymerization rate in… CONTINUE READING

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