Tropomyosin-related kinase B/brain derived-neurotrophic factor signaling pathway as a potential therapeutic target for colorectal cancer.

@article{Akil2016TropomyosinrelatedKB,
  title={Tropomyosin-related kinase B/brain derived-neurotrophic factor signaling pathway as a potential therapeutic target for colorectal cancer.},
  author={Hussein Akil and Aur{\'e}lie Perraud and Marie-Odile Jauberteau and Muriel Mathonnet},
  journal={World journal of gastroenterology},
  year={2016},
  volume={22 2},
  pages={
          490-500
        }
}
Colorectal cancer (CRC) is the second most common cause of cancer-related death in western countries. Approximately one-quarter of newly diagnosed patients for CRC have metastases, and a further 40%-50% experience disease recurrence or develop metastases after all standard therapies. Therefore, understanding the molecular mechanisms involved in the progression of CRC and subsequently developing novel therapeutic targets is crucial to improve management of CRC and patients' long-term survival… CONTINUE READING
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