Tropomyosin receptor kinase inhibitors: an updated patent review for 2016–2019

@article{Bailey2020TropomyosinRK,
  title={Tropomyosin receptor kinase inhibitors: an updated patent review for 2016–2019},
  author={Justin J Bailey and Carolin Jaworski and Do Hoang Tung and Carmen W{\"a}ngler and Bj{\"o}rn W{\"a}ngler and Ralf Schirrmacher},
  journal={Expert Opinion on Therapeutic Patents},
  year={2020},
  volume={30},
  pages={325 - 339}
}
ABSTRACT Introduction: Tropomyosin receptor kinases (Trks) control processes in the fields of growth, survival, and differentiation of neuronal processes. They also play a crucial role in neurodegenerative diseases as well as different types of cancer. Interest in developing Trk inhibitors to target NTRK fusion-driven cancers has escalated in the last decade, leading to the FDA approval of the pan-Trk inhibitors entrectinib and larotrectinib. The development of next-generation inhibitors that… 
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